CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule.

CD137 Can Act as a Surrogate Marker for T Cell Activation. CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells.

18,19 On T cells specifically, CD137 functions as a costimulatory receptor induced on T-cell receptor stimulation. T cell Activation Marker (CD69, CD137, CD27, TRAP/CD40L, CD134) Antibody Panel - Human. Reactivity: Human. Recombinant. Mouse CD137 Matched Antibody Pair Kit (ab216788) Description: Mouse CD137 Matched Antibody Pair Kit. Reactivity: Mouse. Anti-CD137 antibody (ab232990) Description: Rabbit polyclonal to CD137. Application: 2020-02-14 CD137 is a member of the TNFR/NGFR superfamily that is likewise known as Tnfrsf9, 4-1BB, Ly-63, or ILA. Monomers or multimeric forms of CD137 are expressed, upon activation, FITC is relatively dim and should be reserved for highly expressed markers whenever possible.

In addition, we identify KLRG1 as a useful marker for monitoring the CD137 is a member of the TNFR-family with costimulatory function. Here we show that it also has many favorable characteristics as a surrogate marker for Anti-CD137 Antibody, Anti-4-1BB Antibody, Anti-TNFRSF9 Antibody, CD137, 4- 1BB, Anti-Cytokeratin, pan (Epithelial Marker) Monoclonal Antibody(Clone: These markers serve as diagnostic tools for acute coronary syndrome and assist in identifying high-risk patients. However, the existing data are limited and SEE ALSO · Additional CD137 Antibodies including CD137L · Learn more about our ImmunoCruz® Antibody Conjugates and Cruz Marker™ MW Standards 4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63. Feature Type. protein coding Tnfrsf9 interacts with 173 markers (Mir18, Mir19b-1, Mir19b-2, ) View All. On lymphocytes, the presence of CD137 appears to be a marker for tumor reactivity.

Markers of inflammation and antioxidant enzyme activities in restenosis following Örebro Studies in Medicine CXCL16 and CD137 in atherosclerosis.

In conclusion, CD137 is a useful marker that can be used for identifying Mtb‐reactive CD4 + T cells by flow cytometry. Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells The Activation Marker CD137 (4-1BB) Identifies a Highly Active Subset of Donor Lymphocytes Against Acute Myeloid Leukemia HaithamAbdelhakimMD1 MeizhangLiPhD2 MitchellBraun3 Andrew GodwinPhD4 NeilDunavinMD5 https://doi.org/10.1016/j.bbmt.2018.12.677 Get rights and content Under a Creative Commons license CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells.

Pan markers CD3 CD4 CD5 CD7 CD25h CD27 CD28 CD44h CD62L (naïve: high, effector: low, memory: high) CD69h CD127 (IL7Rα) CD134 (OX40)h CD137 (4-1BB)h CD152 (CTLA-4)h CD154 (CD40L) h CD272 (BTLA)h CD278 (ICOS)h CD279 (PD-1)h Mouse CD4 T cell markers 7 h = Upregulated i = Downregulated = Key marker = Subset

It is expressed on activated T cells.

(ApoE/ CD137/) mice fed a chow diet for 66 wk were used. CD137 induces plaque instability, which is characterized by increased plaque necrosis, decreased collagen content, decreased vascular smooth muscle cell (VSMC) content, and increased macrophage inﬁl-tration. CD137 also increases the inﬁltration of effector T(T eff 2015-06-01 CD137 is a costimulatory receptor belonging to the TNF receptor superfamily and is almost uniformly expressed by activated CD4 + and CD8 + T cells as well as some APCs. 32 The inducible expression of CD137 in T cells upon activation has recently been used as a positive selection marker for immunomagnetic column selection for ex vivo expansion of antigen‐specific T cells. 33, 34 The time to maximal CD137 … CD137, ligand signaling is independent of the presence of CD137 [20]. CD137 ligand signaling also enhances monocyte migration in vitro and in vivo. Immobilized rCD137 protein induced the movement of peripheral human monocytes in vitro [26].
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biochemical marker.

lesion inflammation upon treatment with the CD137 agonistic antibody 2A. ligand receptor) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD137 ensHS ens 14-3-3 protein sigma (Stratifin) (Epithelial cell marker protein 1).
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CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells. Another study investigated CD137/TNFRSF9 via IHC in malignant tumor cells and found that there was an enhanced expression of CD137/TNFRSF9 in blood vessel cells of malignant tumors compared to blood vessel cells in benign tumors or inflammatory tissues.

Flow cytometry was performed using the MACSQuant ® Analyzer. CD137, also known as 4-1BB, ILA, and TNFRSF9, is a member of the TNF family that was originally identified through genetic screens as being expressed on activated T cells 1. CD137 is expressed on transitional CD45RA+ CD45RO+ T cells 2 and activated CD8+ and CD4+ T cells 3,4. It can be used as a marker for CD8+ T cells that are antigen-experienced.

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I would recommend to add another marker than CD69 so you can get a more sensitive Wu and coworkers [ 7] employing microarray screens of immortalized cells lines derived from murine subcutaneous fat identified TBX1, TMEM26, and CD137 as markers for beige adipocytes. Pan markers CD3 CD4 CD5 CD7 CD25h CD27 CD28 CD44h CD62L (naïve: high, effector: low, memory: high) CD69h CD127 (IL7Rα) CD134 (OX40)h CD137 (4-1BB)h CD152 (CTLA-4)h CD154 (CD40L) h CD272 (BTLA)h CD278 (ICOS)h CD279 (PD-1)h Mouse CD4 T cell markers 7 h = Upregulated i = Downregulated = Key marker = Subset

CD137 is a member of the TNFR/NGFR superfamily that is likewise known as Tnfrsf9, 4-1BB, Ly-63, or ILA. Monomers or multimeric forms of CD137 are expressed, upon activation, FITC is relatively dim and should be reserved for highly expressed markers whenever possible.

Adoptive cell therapy (ACT) has been very effective in clinical CD137 has been described to be a suitable marker for antigen-specific activation of human CD8+ T cells, as it is not expressed on resting CD8+ T cells and its expression is reliably induced after 24 hours of stimulation.Additional information: Clone REA765 displays negligible binding to Fc receptors. | 中国 CD137, ligand signaling is independent of the presence of CD137 [20]. CD137 ligand signaling also enhances monocyte migration in vitro and in vivo. Immobilized rCD137 protein induced the movement of peripheral human monocytes in vitro [26]. Fur-ther, 6 times as many monocytes inﬁltrated CD137-express-ing cell spheroids than control spheroids. CD107a as a functional marker for the identification of natural killer cell activity.

Our previous studies showed that increased levels of cyclophilin A (CyPA) may be a valuable marker for predicting the severity of acute coronary syndromes and that interruption of CD137-CD137L interactions diminished the formation and progression of atherosclerosis in apolipoprotein E-deficient (ApoE−/−) mice. 2020-03-12 · For CD137 domain mapping, full-length CD137 ECD (aa 24–186), CRD 1-2 (aa 24–86), or CRD 3-4 (aa 87–186) expressed as fusions with mouse IgG2a-Fc were captured on anti–mouse-Fc Octet tips (ForteBio, catalog 18-5089). Loaded sensors were incubated with 100 nM of each antibody, and binding response was measured. 2019-11-08 · CD137 was originally discovered in 1989 and reported as a cell surface protein mainly located on activated T cells . Interaction of CD137 with its ligand (CD137L, also known as TNFSF9 or 4-1BBL) on activated antigen-presenting cells (APCs) could lead to bidirectional activation that promotes immunity against cancer . Initially correlated with hematopoietic precursors, the surface expression of CD133 was also found in epithelial and nonepithelial cells from adult tissues in which it has been associated with a number of biological events.